The group has strong expertise in scientific computing, in the last 8 years applied within systems biology. Emphasis lies in particular on: (i) multi-scale modelling: macroscopic ODE/DDE/PDE, mesoscopic CME/RDME/queueing theory models. Model assumptions, model building, implementation on various platforms and verification (numerical analysis). (ii) system identification: optimisation (local, global), optimisation measures, parameter estimation, model discrimination and optimal experimental design.