The goal of the Saez-Rodriguez group is to acquire a functional understanding of signaling networks and their deregulation in disease and to apply this knowledge to novel therapeutics. Our research is hypothesis-driven and tailored towards producing mathematical models that integrate diverse data sources.
An illustration of how we use our logic modeling method CellNOpt to better understand deregulation of signal transduction in disease. Left: simple pathway model; right: experimental data and match between model simulations and data.
