The research activities of the Mendes group are: 1) development of the widely used biochemical simulator COPASI and other software applications for systems biology, 2) enzyme kinetics characterization for systems biology models, 3) construction of large scale metabolic models (flux balance analysis and full kinetic models), 4) multi-scale modelling, 5) data mining in systems biology, and 6) modelling specific biochemical processes (interleukin-1 signalling, iron metabolism, the pentose phosphate pathway, hepatitis C infection, growth and division in yeast). Prof. Mendes currently leads a group of 7 research associates and 12 PhD students.